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Information Wellness Blog

Detailed Reviews and Guides about energy and informational health and wellness

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July 12, 2025|Editorial

Rife Therapy For Lyme Disease

The book discusses Rife therapy, experimental frequency devices that may help those living with Lyme disease who don’t respond well to antibiotics, become better.

Proponents of Rife machines claim they emit energy waves whose frequencies can destabilise diseased cells like the sound waves from a singer can shatter glass.

Innately Yours Chiropractic Studio

Innately Yours Chiropractic Studio stands out in Colorado Springs with its distinctive approach to wellness. Led by Dr. Codi, this holistic practice emphasizes clearing away interference so the brain and body can communicate more freely; Network Spinal technique offers gentle solutions that promote self-healing while optimising nervous systems.

RIFE Frequency Therapy is an advanced tool that uses specific frequencies to balance imbalances, promote detoxification and cell regeneration, and support wellness journeys. With 56 clinical and third-party studies supporting its efficacy, this technology offers hope to those facing Lyme disease, complex chronic illnesses, autoimmune conditions, mold toxicity or parasite infestation.

At Innately Yours Chiropractic, we are also home to the Sunlighten Amplify III Infrared Sauna. This state-of-the-art medical-grade sauna uses far infrared wavelengths to penetrate deep into tissues and muscles for relaxation, healing, detoxification, and detoxification – with over 50 proven health benefits! Contact us now for more information about this cutting edge sauna technology or to arrange an appointment!

Dr. Codi

Codi grew up in Dodge City. After attending DCHS and KU she received degrees in Spanish Language, Literature and Culture before enrolling at Weill Cornell Medical College for medical school studies. Codi’s interests in health care range from HIV medicine to global and women’s wellness.

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As an expert in systemic therapy for gynecologic malignancies, she is adept at administering standard oral and IV chemotherapy regimens. Additionally, she assists with rotations in gynecological oncology as well as mentoring fellows interested in women’s health issues.

RIFE frequency therapy assists many of our patients on their path towards optimal health by targeting specific pathogenic cells and activating natural detoxification processes within their bodies. It complements chiropractic and holistic approaches beautifully.

RIFE Frequency Therapy

RIFE Frequency Therapy is an innovative technology that uses sound frequencies to aid the body in healing itself. Based on the principle that every cell and organism vibrates at its own frequency, disruption of these vibrations may result in illness or imbalance; Dr. Codi selects specific frequencies which resonate with pathogenic cells in your body in order to suppress their activity and facilitate detoxification.

Royal Raymond Rife was an American scientist known for inventing the Rife machine and developing a universal microscope, enabling visualization of previously unseen microbes. Rife believed that diseased cells possessed their own electromagnetic frequencies that could be delivered directly to them so as to eliminate pathogens without harming healthy tissue; and claimed he successfully treated many illnesses including cancer and tuberculosis with his method.

Though Rife could not duplicate his results to meet medical community approval, his discoveries inspired him to develop an electromagnetic device called the Rife range emitter that generated electromagnetic frequencies and transmitted them directly to the body, which proved capable of killing pathogens responsible for disease as well as providing many other healing benefits. He amassed an extensive list of healing benefits due to its use.

Rife machines were also utilized to treat Lyme disease, an infectious condition spread by infected deer ticks. Unfortunately, many individuals infected with Lyme do not respond well to antibiotics treatment and their chronic symptoms can often remain difficult to resolve as a result of the presence of Borrelia bacteria and co-infections like Bartonella Ehrlichia Babesia which disrupt the natural balance of their bodies microbial ecosystem.

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RIFE Frequency Therapy has been proven to support detoxification, which is necessary for eliminating toxins that can cause symptoms like indigestion, fatigue, joint pain and inflammation. Furthermore, this non-invasive therapy helps reduce stress and promote deeper sleep while simultaneously supporting other holistic therapies like cold laser therapy, Biolight therapy stem cell therapy or botanical intervention.

RIFE Frequency Therapy can be an excellent and safe alternative to surgery and pharmaceuticals, however it is crucial that you work with a trained practitioner who can guide your through this process safely. The best practitioners often combine Rife therapy with IV nutrition therapy and herbal remedy treatments.

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Many patients suffering from Lyme disease become disenchanted with standard treatments, which often involve prolonged antibiotic usage. Overdose of antibiotics can damage a body’s natural microbiome and increase toxicity, potentially leading to the Herxheimer reaction (a detoxification response that causes flu-like symptoms). As such, some seek alternative or complementary therapies such as Rife therapy – an electrotherapy method using electromagnetic waves targeting specific frequencies thought to correspond with bacteria, viruses, and other pathogens.

Borrelia spirochete infection can spread throughout a tick-bitten human’s body, even crossing over into their brain and joints. When caught early and treated appropriately with antibiotics, symptoms typically clear within weeks or so; but sometimes bacteria remain dormant within their system, causing pain months or years after treatment has concluded.

Rifing, an unorthodox treatment approach developed in the 1950s by Royal Raymond Rife of America who claimed that it could destroy disease-causing pathogens without harming healthy cells, has since been discredited by medical associations and government agencies; his claims remain unverifiable.

Individuals who believe they have chronic Lyme disease often complain of medical officials ignoring their symptoms, the difficulty in diagnosis and rarely cure, as well as ongoing co-infections like Bartonella Ehrlichia Anaplasma Babesia that cause long-lasting and complex symptoms that cannot be explained away by one factor alone such as an undiagnosed autoimmune disorder or genetic predisposition.

Some patients believe dietary changes can help eliminate bacteria from the body, such as taking large doses of salt and vitamin C, as well as following an alkaline diet to raise their body’s pH to make conditions inhospitable for bacteria growth. Other patients report benefiting from acupuncture or cranial therapy which involves gently touching energy points on the head to activate them.

Some patients can benefit from light therapy using red light. The near-infrared light produced by red light machines helps promote blood flow and relax muscles, providing temporary relief of tension and pain. Others report improved vision after receiving a cranial session which involves performing surgery on the eye’s specialized nerve tissue.

July 12, 2025|Editorial

Hulda Clark Zapper

Hulda Clark was a naturopathic doctor and author who advocated that parasites were at the core of all disease. To combat them, she created the “Zapper,” an electrical signal device to kill parasites while strengthening immunity.

For optimal results, use every day for best results. Some individuals may experience mild detox symptoms like nausea or dizziness for a few days after beginning.

What is a Zapper?

Zappers are low-voltage devices designed to kill parasites, bacteria and viruses with electrical energy. According to Hulda Clark’s theory that all living things transmit specific frequencies that contribute to disease including cancer; she suggested using her Zapper device as an effective way of eliminating parasites and toxins from one’s body.

Zappers differ from traditional insecticides by not containing poisonous chemicals; instead they attract and electrocute flying insects that land on them using a metal grid. Zappers work best when used between dusk and dawn when many bugs are attracted to light – mosquitoes especially are known for being positively phototactic, meaning that they move towards bright lights rather than away from dark ones.

Original zappers consisted of an electronic circuit capable of producing pulses at 30kHz frequency and a battery, two copper handles called electrodes for holding in your hand or placing on various parts of your body, low impedance leads connected to these handles, short circuit protection, battery polarity protection and short circuit protection, short circuit warning systems. pregnant women or those who possessed electronic implants like pacemakers should avoid using them as these can lead to dangerous shockwaves being generated within your body.

Hulda Clark’s Zapper

Hulda Clark was a biophysicist and naturopath who dedicated years to investigating the root causes of chronic illness. Her groundbreaking research disproved long-standing medical assumptions with quantifiable bioenergetic data, showing how parasitic and microbial disturbances often played an integral part in chronic fatigue, autoimmune dysfunction and other ailments. Clark created a compact device called Hulda Clark Zapper that delivered specific frequencies to neutralize these organisms; today this tool remains popular as an aid for detoxification and immune system restoration.

Hulda Clark’s Zapper Hulda Clark stands out in an industry filled with quick fixes and overblown devices by being both effective and trustworthy. Based in biophysics and built for bioelectric restoration, this reliable frequency device continues to outperform expectations even decades after it first debuted.

Clark’s Zapper consists of a box that houses components for creating an electric field to kill parasites and microorganisms such as flukes, roundworms, mites and bacteria. A positive offset electrical signal disrupts membranes of these organisms causing them to burst and die, so it is highly recommended to use it on bare skin in order to avoid irritation or burns.

Original versions of zappers used a fixed frequency of 30kHz that was found effective against certain pathogens. This invention expands upon this concept by enabling users to choose their desired frequency from up to 1 million Hz frequency range.

This device introduces several new features that increase usability and safety, such as automatically alerting the user if their battery power drops below 20% before beginning zapping sessions. Furthermore, it features a “Sync” button to sync up with computers to update firmware on the zapper itself.

The VariZapper features advanced electronics to deliver frequency accuracy between 0.1 Hz and 1 million Hz, and includes a rechargeable internal fitted battery with battery life indicator. Furthermore, an optional program driver card provides preset frequency programs containing target diseases with their associated frequencies.

Hulda Clark’s Swing Zapper

Hulda Clark created her Zapper device in 1995 as an electronic device emitting low-frequency electrical pulses to disrupt parasites and restore overall health. Based on Clark’s belief that parasites were at the core of many illnesses and ailments, Clark believed removing parasites could restore people to regaining their natural vitality and lead to longer, healthier lives.

Original Zapper was a small hand-held device powered by a 9-volt battery and pulse generator circuit to transmit frequencies, connected with copper handles or electrodes that the user could hold or place anywhere on their body for use. Low frequency current reversed diseased cell polarity to kill them off while stimulating white blood cells and healing delicate tissues at the same time; Clark’s Zapper could even eliminate parasites that were hiding within cysts or smaller areas on your body.

Clark was widely renowned for her highly controversial methods and theories; nonetheless, she persisted with her work unimpeded. She developed various herbal remedies and devices (including the Zapper) to treat her patients; now widely practiced by alternative medicine practitioners.

Clark originally designed her zapper using a fixed frequency of 30kHz and voltage lower than 9V. Her device became the basis of numerous patents by Patrick Murphy, Janet Fleming, and Craig Story–including U.S. Patent Nos 8,781,573 by Patrick and U.S. Patent Nos 5,690692 by Janet, as well as U.S. Patent No 5.925071.

Don Croft’s zappers use an effective frequency of 17kHz at 27V that has proven more than enough to neutralize most pathogens without harming healthy tissue. Furthermore, these Orgonite-infused devices contain Orgonite materials to enhance and refine subtle energies within the body.

These zappers have been rigorously tested to ensure your safety when used, and may be combined with herbs or supplements to maximize results or be used as preventive measures against harmful parasites. We invite you to explore our collection of zappers today!

Hulda Clark’s Books

Hulda Regehr Clark (1864-1948) was born in Germany. At two years old, her family relocated to Wisconsin before relocating further west in Minnesota before traveling by wagon to Woodland near Lewis River bottoms near Woodland near Woodland where they stayed in a cabin covered with roses.

Clark asserted in her 1995 book, The Cure for All Diseases” that all diseases were the result of parasitic infection and that using fixed frequency devices known as zappers – electrical signals of 30kHz and 8-9V with positive offset – can effectively disable pathogens and cure disease.

Thousands of people credit Clark with helping them, yet the medical establishment has ignored her. Now, a new book tells her story-a tale of truth buried under fear and greed-that will revolutionize how you perceive medicine and healing. You can purchase your copy via Amazon or directly at HuldaClarkBook.com

July 12, 2025|Editorial

Benefits of Vibration Therapy

Vibration therapy helps the body’s natural pain-relief mechanisms by blocking pain signals and stimulating endorphin release, as well as improving joint lubrication to decrease stiffness and increase flexibility.

People with heart, muscle or medical implant issues should avoid using vibration plates; additionally, their use should not be recommended during pregnancy.

Improved Circulation

Vibrations generated by a vibrating platform stimulate muscles, joints, and bones to contract and relax, increasing muscle strength, flexibility, blood circulation and overall performance. Whole-body vibration (WBV) therapy has become popular among fitness instructors as a method to enhance performance and recovery from injuries; it may even help alleviate symptoms associated with conditions like chronic pain or osteoporosis. Localized vibration (LSV) uses handheld devices that deliver concentrated streams of vibrations directly to specific muscles or joints for treatment.

Vibration plates can help improve your mood by stimulating the release of neurotransmitters such as serotonin and dopamine, two chemicals which play an essential role in emotional regulation, helping you feel calmer and more positive about life. They may even decrease stress hormones which contribute to anxiety and depression – an additional advantage of adding vibration therapy into psychotherapy or mental health treatments plans as this enhances their effectiveness.

Gustav Zander pioneered vibration therapy during the late 19th century when he used mechanical vibration machines to help recover patients from physical injury or illness. His efforts led to later advancements of this therapy; American physician and entrepreneur John Harvey Kellogg later used steam-powered vibration equipment at his Battle Creek sanitarium in Michigan for strengthening strength and mobility among frail elderly persons.

Many individuals today are exploring vibration therapy as a possible means of treating their health concerns, but before beginning this path it’s important to fully understand how it works and the risks involved.

Vibration therapy has been scientifically demonstrated to significantly enhance musculoskeletal strength, balance and posture. Furthermore, it has also been shown to boost bone density and slow age-related muscle loss (sarcopenia). These effects are due to vibration therapy stimulating muscle spindles – tiny sensors found at the ends of muscles that inform your brain how much your muscles stretch or contract, and help your body maintain muscle strength.

However, it’s essential that frequency and intensity of vibrations be tailored specifically to each person based on your medical conditions – for instance heart problems or deep vein thrombosis could interfere with vibration therapy; additionally, pregnant women or those with pacemakers are not advised to undergo this therapy.

Relieved Pain

Vibration therapy aims to alleviate pain caused by certain health conditions and injuries, including fibromyalgia, arthritis and chronic pain disorders such as Parkinson’s. Vibration therapy may also be effective against stiffness and tremors in these instances.

Vibration can stimulate muscle spindle endings, tiny sensor-like receptors that inform your brain how much your muscles expand or contract, providing crucial feedback about how to relax, move or stand effectively.

Studies show that vibration therapy can reset the abnormal firing of neurons responsible for Parkinson’s symptoms such as tremors and slow movement, via coordinated reset stimulation – using patterned stimuli to stimulate your body’s neurons systematically. Treatment sessions last just 10 minutes each so you can easily fit them into your daily schedule.

Better Mental Health

Vibration therapy works to strengthen the connection between mind and body, helping individuals better manage stress and regulate their moods. Furthermore, vibration therapy promotes sleep as an integral component of mental wellbeing – which in turn allows individuals to feel more refreshed and mentally sharper for improved performance in everyday tasks.

Vibration therapy also activates cells that form bones, increasing bone density. Therefore, Russian space program used vibration therapy to assist astronauts with reducing muscle stiffness and increasing bone density – so they could stay longer in space than American counterparts.

Vibrations stimulate neurotransmitters like serotonin and dopamine, essential in maintaining emotional equilibrium and managing mood disorders. Furthermore, improved blood flow reduces anxiety while providing energy boosts resulting in a healthier mental state overall.

Integrating vibration therapy with psychotherapy can provide an holistic approach to mental health, with reduced tension and enhanced circulation helping individuals be more open to therapeutic techniques and discussions. Furthermore, vibration therapy may improve medication adherence by encouraging better physical health while alleviating pain symptoms. However, certain conditions and situations, such as cardiovascular disease or deep vein thrombosis may make vibration therapy unsafe; so always consult with your healthcare provider prior to engaging in vibration therapy treatment. Furthermore, pregnancy women and those with pacemakers or similar devices are advised against engaging in vibration therapy treatment as it could potentially harm them as it could potentially aggravate symptoms caused by these devices.

July 11, 2025|Editorial

Tinnitus Sound Therapy – Finding Frequencies That Work

Sound therapy can help alleviate the distressing effects of tinnitus and help you remain focused. You may opt for soothing sounds like white noise or ambient music; alternatively, a fan or humidifier with a continuous background hum may work better for some.

Unfortunately, many tinnitus sound therapy videos available online are of poor quality. Patients typically select videos based on high views or like counts; however, this approach often leads to subpar results.

Frequencies for Tinnitus Relief

Tinnitus, or the auditory perception known as phantom auditory perception, can be an ongoing struggle for many people. Studies show that approximately 35% experience it chronically while 10-15% suffer heavily due to it (Langguth et al, 2013). There are various kinds of sound therapy designed specifically to treat this condition – most typically by playing music or sounds which mask it; such as white noise, nature sounds or rain – in order to retrain the brain away from focusing on it and towards something else (Langguth et al, 2013).

One approach involves creating a tone that matches the frequency of your tinnitus sound, which has proven successful in over 90% of cases (Langguth et al., 2013). Unfortunately, however, this technique can be difficult and frustrating to master without first consulting an audiologologist; fortunately there’s now an easier and convenient option available that makes sound therapy for tinnitus an accessible home solution – all it requires are quality headphones!

Download a tinnitus app onto your mobile device and play the sound associated with your tinnitus for at least four hours per day, such as when doing other activities (including going to sleep). These sounds don’t mask or disguise tinnitus; rather they aim to retrain the brain to ignore and give less importance to this sensory input – however this process requires long-term dedication.

Other sound therapies for treating tinnitus have included tailor-made notched music training (TMNMT) and fractal tones. TMNMT uses an individually customized frequency notch tailored to their own tinnitus frequencies to decrease brain activity related to it via lateral inhibition allowing activation of neurons near but sparing the frequency associated with their symptoms – it has even been demonstrated effective through randomized controlled trials lasting three months!

Other studies utilizing binaural beats with different carrier frequencies have also produced promising results for relieving tinnitus, including modulating neural activity in the limbic system, decreasing stress and anxiety levels and improving vigilance, memory capacity and creativity. One study using 8Hz beat frequency with 50Hz carrier wave reduced disturbance ratings on questionnaire-based measures by an average of 5.81 points among 26 patients; its effect was greatest for those who participated in sound therapy for more than one hour daily. Research findings indicate that continuous sound therapy may provide an effective means of relieving tinnitus for some patients; however, more study needs to be conducted in order to maximize benefits and determine the duration of therapy sessions. If you would like more information about tinnitus sound therapy at our clinic and would like an assessment, please get in touch.

Tinnitus Frequency Chart

The Tinnitus Sound Therapy Chart is an invaluable tool that assists individuals in finding frequencies effective at masking tinnitus. It works through a simple yet powerful strategy: matching the frequency of your tinnitus with that of an audio track. In doing so, tinnitus becomes effectively drowned out by matching its specific frequency against that in an audio track – this ultimately results in suppression. While white noise or pink noise might help some, more effective results come from using notched audio programs specifically tailored towards masking your tinnitus.

The basic idea behind the Tinnitus Relief Frequency Chart is that hearing loss typically results in reduced external sound stimulation reaching the brain, leading to maladaptive neuroplastic changes and eventually leading to Tinnitus. By providing a spectrum of frequencies that differ from that of Tinnitus pitch, it’s hoped these differences will disorienting brain signals and cause Tinnitus intensity or silence to decrease or completely disappear altogether. Frequencies will vary depending on Tinnitus frequency; lower or higher-frequency sounds could work.

Studies on different frequency selections have yielded promising results, such as when notched frequencies were used to suppress mild tinnitus for several hours every day for several days – showing that 90% of times they successfully concealed it.

Another recent study investigated the efficacy of 10 Hz amplitude modulated and unmodulated sounds (pure tones, noise and music) to temporarily suppress tinnitus loudness. Their results demonstrated that modulated sounds elicited greater temporary loudness suppression than unmodulated sounds; however, notched filters width was more significant in providing relief than sound intensity alone.

Other treatments for tinnitus exist as well, such as masking, retraining and sound therapy. While these methods can help alleviate symptoms of tinnitus, they don’t work for everyone and often take time before becoming effective. Furthermore, many individuals with tinnitus find certain sounds or medical conditions make treatment more challenging or ineffective.

Cochlear implants offer another method for relieving tinnitus: these surgically implanted devices restore hearing loss due to severe tinnitus or deafness, increasing outside sound stimulation to distract the brain away from hearing the tinnitus, thus decreasing its intensity or volume. Cochlear implants should only be considered by those deemed severe enough by an audiologist, since implantation procedures and associated risks pose substantial health and financial consequences for them and their users.

Tinnitus Relief Frequency Chart

Sound therapy has been demonstrated to significantly alleviate tinnitus symptoms. Some methods involve binaural beats, created by combining two distinct frequencies together into an audible rhythmic tone; others use white noise or tonal sounds as distractions from focussing on it; cognitive behavioral therapy and relaxation techniques can also provide relief from tinnitus symptoms.

Many YouTube tinnitus sound therapy videos exist; however, their quality varies significantly. Most provide information unsuitable for medical education or unsubstantiated claims. A recent study assessed YouTube tinnitus sound therapy videos and discovered that most were of poor educational quality; authors speculate that such videos may promote false hope as well as various ineffective treatments.

Tinnitus sound therapy frequency charts can assist those experiencing tinnitus to find sounds that match up with their symptoms and provide relief. Tinnitus sound therapy charts can be an invaluable asset for individuals seeking relief from their tinnitus and improving quality of life; simple to use and available free online. Please be aware, though, that this relief sound chart only applies for frequencies between 2000 Hz and 6000 Hz; other frequencies require full assessment for proper diagnosis and treatment planning.

In this study, the authors utilized a large number of tinnitus sound videos uploaded by professional bodies and individuals on YouTube. Their authors discovered that videos produced by otolaryngologists exhibited higher understandability and quality scores compared to videos created by other individuals or organizations; moreover, YouTube’s algorithm for video recommendation takes into account views and interaction index for videos; so their popularity may influence it to recommend itself regardless of its content.

To establish an effective relief sound for tinnitus sufferers, the authors used a computer program to generate acoustic stimuli that corresponded with each participant’s specific frequency fT of their tinnitus symptoms. In their experiments, the authors discovered that this tinnitus relief sound could significantly reduce loudness of participants’ tinnitus symptoms. This finding was in line with previous studies which employed notched noise, white noise, BBN and water sound to alleviate tinnitus symptoms. The authors of this study concluded that some participants found relief through these sounds but further investigation is required in order to validate these results.

July 11, 2025|Editorial

Wave Genome Ra

Wave Genome Ra is an innovative new approach for identifying pathways associated with RA using gene expression data. It uses GWAS, gene expression analysis and adaptive permutation tests to find those significantly associated with the condition.

Core promoter architecture is distinguished by an abundance of TATA boxes7 and sharp transcription initiation profiles.8, in contrast with miR-430 genes which exhibit more open chromatin signals at 256 cell stage.

What is a wave genome?

The Wave Genome Hypothesis proposes that waves of gene expression appear, peak, and fade sequentially during early development. Each wave corresponds to a genomic sequence or chromosome which contains multiple genes with unique activation patterns – ZGA (Zygotic Gene Activation) is usually observed during 2-cell to 4-cell embryo stages while minor waves peak between sphere/dome stage and morula stage; all waves are initiated by single enhancers.

MiR-430 cluster and other members of the minor wave become active during ZGA wave activation due to open chromatin states and histone modification marks like H3K27ac. Publicly available epigenomic datasets representing ATAC-seq chromatin opening, transcriptional activity states in early development (RNA-seq), and presence of cis-regulatory elements (ChIP-seq) were utilized to define DNA sequence features and promoter architectures that distinguish minor wave genes from their neighbors.

MiR-430 genes proximal to transcription bodies exhibit a distinct promoter architecture in which no sharp transcription start site (TSS) exists and instead a broad promoter region extends inward towards transcription start site. These promoter regions may be targeted by H3K27ac targeting histone modifications, and possess unique core promoter architecture from those activated during the zygotic phase.

Histone modification mark H3K27ac was significantly less prevalent in miR-430 promoter regions compared with CG sets, suggesting that their unique activation profiles might be related to its lower abundance in these promoter regions; suggesting a more restrictive environment is required for their expression.

WAVE GENOME LLC provides one of the world’s most advanced rejuvenation treatments: A Digital Biohologram of each client’s Wave Matrix is coded onto a microchip and read by a bio-holographic TESLA generator, transmitting nanolevel signals through nanoholography to client cells to promote profound increases in health and rejuvenation of entire organism. TESLA GENOME is the result of years of research by some of the world’s most advanced scientific groups including Bauman Russian State Technological University (MIT level), former USSR research institutes specialising in psychotronics research institutes.

What is a wave genome ra?

Wave Genome LLC has designed a new generation of Psi-Generators that are based on electret technology, used for decades in Russia with great success. However, unlike previous devices that simply coded electrets with frequency drugs or supplements for rejuvenation purposes, Wave Genome LLC pioneers bioholographic wave treatments for rejuvenation purposes using an electret device containing each client’s wave matrix encoded as biohologram and delivered as part of this treatment protocol.

These personalized digital drugs are tailored specifically for each client according to Dr Irene Caesar’s theory of Wave Optics in Chromosomes, sold either through Tesla Human Cell Digital Pharmacy (TESLA HUMAN CELL DIGITAL PHARMACY); or Remote Laser Treatment, depending on their choice.

What is a wave genome pg?

WASP and WAVE proteins play an integral role in various actin-based cell structures, including endocytic vesicles, filopodia and podosomes/invadopodia. How these diverse architectural shapes are constructed through similar molecular actions is still one of the great mysteries in cell biology; their discovery may hold important ramifications for tumor growth, cell motility and blood vessel formation during embryonic development.

Recently, it has become clear that N-WASP plays an essential role in the formation of different structures by recruiting other proteins to form complex networks that sculpt actin cytoskeleton. N-WASP forms a homopentameric protein complex with Sra1 and Nap1, two other members of WAVE family; Abelson interactors Abi1/2/3 (also known as Nap2 in Drosophila); its core is made up of proline-rich VCA domain which simultaneously binds two proteins at once to initiate polymerization initiation of actin polymerization initiation of actin polymerization of actin polymerization initiation.

N-WASP and WAVE proteins also interact with GTPase Rho, which facilitates reorganization of actin cytoskeleton in an intricate fashion influenced by additional signaling pathways. Rac can directly bind to WAVE1 and WAVE2 basic domains via its SH3 domain to recruit them to membrane. GTP-loaded Rac may also bind with the RCB/IMD domain of IRSp53 from the EF-C/F-BAR family and thus indirectly regulate WAVEs through this interaction.

Though the origins of N-WASP and its family remain obscure, phylogenetic analyses based on alignment of highly conserved WH1/EVH1 domains indicate they originated prior to divergence of eukaryotic cells. Additionally, identification of WAVE and WASP homologs in plants suggests that development of Arp2/3-based actin polymerizing machinery was essential in multicellularity evolution.

What is a wave genome cg?

Wave genome Cg (WGCg) is an embryonic stem cell gene whose promoter is activated by pioneering transcription factors, including Nanog in Drosophila8, Pou5f3 and Sox19b in Xenopus9,8,10, BRD4 in human13 have all been demonstrated as key core promoter elements during ZGA13,15 binding H3K27ac marks on chromatin then activating major waves 16-17 of ZGA based on TATA box presence and sharp transcription start site (TSS) profiles16-17

This evidence supports the theory that major and minor waves are two distinct genomic activation events and that their emergence is managed by specific promoter architectures. Therefore, it should come as no surprise that major wave genes tend to respond better to pioneering factor binding than minor wave genes.

Additionally, we observed that minor wave genes were highly enriched for nascent RNA and active RNA Polymerase II speckles while major wave genes showed minimal enrichment; this suggests that their respective chromatin environments were more conducive to transcription than that around major wave genes; consistent with previous findings that permissive transcription states are correlated with reduced genome mutation rates.

At our lab, the differences between major and minor wave genes were further investigated using sequence analyses of promoter architecture. Major wave genes displayed broad TSS profiles while minor wave genes displayed more limited ones with canonical TATA boxes and canonical TSS profiles. Furthermore, we observed that only minor wave genes managed to avoid global transcriptional repression while major wave ones could not.

Minor wave genes often exhibit more limited promoter regions and lack TATA-box-dependent, sharp TSS core promoter codes than major wave genes; as a result, minor wave genes may not respond directly to pioneering factors through interactions between TATA-box dependent promoter sequences and pioneering factors; on the other hand, major wave genes tend to respond better in such instances.

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