Reversing aging with pills seems far-fetched, yet new research shows it might actually become possible in near future.
Scientists have discovered a drug cocktail to extend mice lifespans while protecting against age-related frailty and disease. Some of these drugs are already commercially available while others are currently undergoing human cellular trials.
1. Vitamin C
Vitamin C is an anti-oxidant nutrient with multiple benefits for immunity, skin protection and degenerative disease prevention. Furthermore, vitamin C promotes detoxification processes within cells while also aiding inflammation reduction – making it an indispensable daily dietary source.
Researchers recently conducted a study published in Aging journal which identified chemical drug combinations which reversed aging by altering cell epigenetics. Loss of epigenetic information leads to changes in gene expression, loss of cell identity, mitochondrial dysfunction, inflammation and cell senescence – hallmarks of cellular aging.
Vitamin C is frequently utilized in intravenous infusion treatments such as Myers Cocktail to boost immunity, treat chronic fatigue, help allergies, and lessen symptoms of fibromyalgia. When administered intravenously, blood concentrations can reach many times greater than when taken orally.
2. Coenzyme Q10
Coenzyme Q10 is an essential nutrient involved in energy production within cells. Additionally, it serves as an antioxidant, with studies suggesting it may improve symptoms associated with mitochondrial dysfunction and oxidative damage. While naturally found in food sources such as fish or meat products, Coenzyme Q10 supplements can also be taken by mouth as dietary supplements containing 10 isoprene units attached to its benzoquinone head – fat-soluble substances which cross over into brain circulation quickly are also possible with this form of supplementation.
One study demonstrated how selenium and coenzyme Q10 combined reduced levels of oxidative stress in those suffering heart failure while increasing survival rates; further investigation must take place to demonstrate whether this combination truly improves outcomes.
Coenzyme Q10 taken orally appears to reduce fatigue and muscle weakness for people living with multiple sclerosis, prevent or slow the progression of nerve pain in some individuals living with diabetes, improve mobility in mitochondrial myopathies (group of disorders that cause muscle weakness) as well as help ease discomfort associated with fibromyalgia. Furthermore, higher doses may also lower triglyceride and LDL (or “bad”) cholesterol levels while simultaneously decreasing severity of chest pain known as angina – it might even lower triglyceride and LDL (“bad”) cholesterol levels but higher doses would likely need to take effect.
Low levels of Coenzyme Q10 may increase risk for death from cancer and heart disease as well as reduce mental function for older people, possibly impairing how people think and possibly decreasing effectiveness of antipsychotic medication; however taking coenzyme Q10 doesn’t seem to benefit people living with Alzheimer disease or Parkinson disease.
3. Vitamin E
Vitamin E is a fat-soluble vitamin stored in fatty tissues and the liver, and functions as an antioxidant to protect body tissues from being damaged by free radicals. Studies have demonstrated its ability to help protect against certain chronic diseases such as dementia. Furthermore, further research may reveal its ability to delay cognitive decline associated with age. [47]
As with other nutrients on this list, vitamin E offers multiple advantages and should be combined with them to maximize their effects. For instance, saw palmetto can help prevent prostate problems, milk thistle supports liver health, and ginko biloba helps with circulation; when taken together they have an anti aging effect.
4. Alpha Lipoic Acid
Alpha lipoic acid (ALA), also known as thioctic acid, is one of the few powerful antioxidants available that can exist both as fat- and water-soluble forms, making it stand out among its peers as an agent capable of protecting us against free radical damage while strengthening existing antioxidant defense mechanisms.
ALA is produced inside mitochondria–the powerhouses of your cells–where it helps enzymes transform energy in food into usable energy for your body. Unfortunately, with age comes decreased production; taking high quality dietary supplements is the best way to replenish this depleted source.
Recent studies have demonstrated how yoga can prevent and reverse the aging process in various ways, from increasing skin elasticity to slowing the formation of fine lines; helping prevent cholesterol oxidation in your bloodstream to improving cardiovascular health; helping with diabetic neuropathy pain relief as well as reducing pain, tingling and numbness caused by high blood sugar levels; helping manage high blood pressure conditions to managing blood sugar in people without diabetes; as well as helping reduce blood sugar for people who already have it!
Studies have also suggested that ALA may assist in memory loss and Alzheimer’s disease, both associated with oxidative stress. Laboratory and animal research shows ALA to be effective at preventing their onset; more research needs to be conducted with humans. Furthermore, carpal tunnel syndrome appears to respond favorably; lab and animal studies demonstrate this treatment’s preventative properties; more human research needs to be completed though. ALA also appears effective against carpal tunnel syndrome which is an uncomfortable wrist condition caused by numbness, tingling and sensitivity; finally it chelate some pro-oxidant minerals offering detoxification in our bodies while balancing out our overall cellular defense systems while helping create glutathione – another powerful anti-ageing agent!
5. L-Glutamine
L-Glutamine serves as both an energy substrate and fuel source for many cells in the body, particularly immune system cells, with immune cells using glutamine at rates similar to glucose even under limited nutrition conditions like malnutrition or sepsis.[1] Oral administration of L-Glutamine appears safe at doses up to 21 grams daily with side effects mainly being digestive such as constipation or bloating being rare occurrences[2]
Glutamine has been demonstrated to enhance endurance exercise performance and decrease perceived fatigue by decreasing ammonia accumulation in muscles.[5] Additionally, glutamine stimulates leukocyte proliferation while attenuating pro-inflammatory cytokines such as interleukin-6. Additionally, HSP70 and other anti-inflammatory molecules increase in production as does anti-NFB cytokines which work against NFB production.
Transcriptomic rejuvenation provided by OSK and six chemical cocktails (C1-C6) significantly decreased the biological transcriptomic age of senescent NCC cells, with cocktail C1 producing the greatest impact – bringing down their transcriptomic age below that of non-senescent controls. Furthermore, molecular mechanisms suggested these compounds worked as epigenetic reprogrammers by restoring degraded epigenetic information.
C1 is the most potent chemical cocktail, consisting of forskolin and B-methyl tyrosine as adenylyl cyclase activators; both act as ligands for AMPK – an essential cellular regulator that binds threonine and glycine in mitochondrial matrix to initiate phosphorylation of mTOR, thus regulating several pathways including cell growth and differentiation. Selenomethyl L-alanine also activates adenylyl cyclase and has been demonstrated to induce reprogramming within cell populations.
