Resveratrol exhibits multiple bioactive properties, such as antioxidant, anti-inflammatory, cardiovascular protection and cancer prevention properties. Furthermore, it displays antiaging effects by alleviating oxidative stress, relieving inflammation reaction and improving mitochondrial function as well as regulating apoptosis regulation.
Oxidative stress is a primary contributor to aging and age-related diseases, including cardiovascular conditions such as hypertension. Lipid peroxidation and protein carbonylation damage cell structures and functions, leading to irreparable damage. Resveratrol can reduce ROS generation while restoring cell redox balance, thus exerting an antiaging effect.
Inhibits oxidative stress
Oxidative stress occurs when there is a discrepancy between the amount of free radicals produced and those removed by the body, which results in damage to cellular components such as lipids, proteins and DNA. In order to counter this oxidative damage the body produces endogenous and exogenous antioxidants such as glutathione, superoxide dismutase, catalase as well as non-enzymatic antioxidants like flavonoids and polyphenols which help defend cells by neutralizing excess free radicals oxidative stress by neutralization of excess free radicals.
Resveratrol, a natural polyphenol compound, can reduce aging by increasing lifespan of osteoocytes. Furthermore, it reduces oxidative stress and enhances autophagy in osteoblasts; researchers believe resveratrol blocks this process via interactions between AMPK and JNK pathways; multiple studies indicate it activates anti-ageing SIRT1 protein associated with autophagy while increasing dendritic spine density and length promoting neuronal autophagy in ischemic brain cells.
Another study demonstrated how resveratrol prevented postmenopausal osteoporosis in rats by mitigating oxidative stress and stimulating autophagy. Researchers utilized an OVX group rat model with ovarian failure and examined its effects on cortical bone of proximal tibias osteocytes, finding reduced levels of SOD, catalase and total antioxidant capacity (tAOC), but significantly higher activities and expression levels of these antioxidant enzymes when exposed to resveratrol.
Researchers then examined resveratrol’s effect on oxidative stress and apoptosis in human hepatoma cell lines, finding that it activated autophagy while also protecting from damage by blocking mitochondrial apoptotic pathways and inhibiting cytochrome C degradation. Researchers also discovered that resveratrol promoted the expression of Klotho gene. This transcription factor regulates cell metabolism and longevity. The study suggests that resveratrol may provide therapeutic benefit in Alzheimer’s, Parkinson’s and Huntington’s diseases. Furthermore, the findings demonstrate how it can prevent the hyperplasia of skeletal muscles due to ovariectomized rats by delaying cartilage degeneration.
Reverses cognitive decline
Studies have demonstrated that resveratrol can significantly slow cognitive decline. Furthermore, it increases neurogenesis while protecting neurons from oxidative stress and death, potentially helping prevent Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS). Resveratrol’s antioxidant properties may even extend lifespan in mice – however these results should only be seen as promising since only lab animals were tested. Further, we don’t yet know how it will work with humans or whether it will have the same results when applied directly – unlike calorie restriction or exercise would.
Scientists are researching ways to enhance the effects of resveratrol in humans. One approach involves creating synthetic molecules that mimic natural resveratrol molecules; such compounds are known as sirtuin activators or STACs and activate SIRT1 proteins found in animal models. STACs have been found to extend life span and longevity as well as decrease cancer, neurodegeneration, and cardiovascular risks; some such examples of STACs include Resveratrol, SRT1720 and SRT2104.
Resveratrol is an anti-inflammatory compound which may help to protect against Alzheimer’s disease. It works by blocking production of proinflammatory mediators like cytokines and chemokines; inhibiting NF-kB activity – an essential signaling pathway involved with both aging and inflammation; as well as increasing glutathione levels within cells to minimize oxidative damage formation.
Resveratrol helps reduce inflammation by inhibiting activity of the enzyme cyclooxygenase I (COX-1). This action is key in decreasing systemic inflammation that contributes to heart disease and other chronic illnesses.
Some individuals are taking resveratrol supplements in an attempt to extend their lifespans, but it’s important to keep in mind that since resveratrol supplements are unregulated by the FDA, it’s hard to be certain you’re getting an optimal dose and side effects may include nausea, diarrhea and vomiting. Experts advise consuming one gram of resveratrol per day either through red wine consumption or supplements.
Reverses osteoporosis
Aging involves complex chemical and physical processes that include cell senescence, which damages DNA and proteins and leads to health issues. Resveratrol is an anti-aging compound which increases cell lifespan while inhibiting cell senescence; additionally it stimulates autophagy–an immune response process which recycles damaged proteins and organelles through autophagy–for recycling purposes.
Resveratrol is well known for its anti-aging and osteoporosis-protecting effects, but also as an aid against osteoporosis. Studies have demonstrated its impact in increasing bone density and decreasing the risk of fractures among postmenopausal women. Resveratrol’s effect may lie within its ability to regulate autophagy; however, its exact mechanism remains unexplored.
Osteoporosis can be caused by various factors, including increased oxidative stress, low nutrient levels and reduced bone formation. Oxidative stress has been linked to decreased activity of osteoclasts responsible for bone remodeling due to activation of the apoptosis pathway and inhibition of autophagy processes.
Resveratrol’s effects on osteoclast apoptosis have been studied using both in vitro and in vivo models. Rats were ovariectomized, then given either resveratrol or saline daily for 12 weeks after being treated with BALP and osteocalcin as measures of bone formation, or b-CTX and Tracp 5b as markers of bone resorption markers – bone biomarkers like BALP, osteocalcin, b-CTX Tracp 5b also measured to determine changes. Resveratrol treatment significantly increased bone mineral density (BMD) while T-score of the femoral neck; improvements were directly proportional with improvements seen in baseline bone biomarker levels as measured from baseline measurements.
Resveratrol is a polyphenol found naturally in grapes and other plants, with three polar hydroxy groups which interact with target proteins to alter their function and modulate their amino acid side chains. Furthermore, resveratrol can activate SIRT1 gene for cell senescence and longevity – this has the ability to slow down age related degenerative conditions while prolonging lifespan in mice; furthermore improving osteoporosis among humans as well as other mammals.
Extends lifespan
Resveratrol, a phenolic compound commonly found in many foods like peanuts, pistachios, grapes and red wine is known for its anti-aging effects in several animal studies. Reduces oxidative stress, inhibits low-grade inflammation, improves mitochondrial function and modifies gut microbiota while protecting against neurodegenerative diseases like Alzheimer’s and Parkinson’s diseases. Preventing and delaying atherosclerosis development. Reducing atherosclerotic plaque, increasing bioactive nitric oxide production levels and restoring endothelial cell redox balance is also possible with regular exercise. This compound can reverse age-related decline in cognitive performance and memory ability in mice. Studies have demonstrated its ability to promote differentiation of adult hippocampal precursor cells into neurons. Furthermore, this compound reversed atherosclerosis in rodents by lowering cholesterol and blood glucose levels, as well as protecting against atherosclerosis for those genetically predisposed.
Resveratrol is an effective antioxidant known to significantly extend animal lives. Its anti-aging effects can be attributed to activating sirtuins and reducing oxidative stress and inflammation while improving mitochondrial function and enhancing cellular survival. Furthermore, Resveratrol mimics caloric restriction which has long been known to lengthen lifespan in many organisms.
Resveratrol has been shown to slow vascular aging in mice, and was reported as increasing lifespan by 20% – though these results should not be used as evidence that resveratrol has anti-ageing benefits in humans.
Early studies on resveratrol’s life-extending properties were intriguing; however, new research has cast doubt on such claims. Researchers found that resveratrol may not cause overexpression of Sir-2 gene in flies and worms which is believed to extend lifespan; moreover resveratrol appears to prevent atherosclerosis by decreasing accumulations of oxidative damage while simultaneously increasing expressions of anti-ageing proteins such as CAT and SOD which help prolong lives.
Resveratrol’s ability to inhibit carcinogenic activation by blocking cytochrome P450 enzyme is particularly intriguing. Additionally, it has also been found to protect against cancer through blocking DNA repair mechanisms and anti-apoptotic signaling mechanisms.
