What would you do in an ideal world where longevity medicines could reverse aging? Such alluring counterfactuals have no basis in science.
Sinclair’s daily regimen entails taking 1 gram of metformin for type 2 diabetes, baby aspirin, resveratrol and three vitamins; his calories are kept low by restricting carbohydrates while eating lots of plants.
Nutrition
Sinclair, as a scientist specializing in molecular causes of aging, understands he could extend his lifespan significantly if he were to reverse aging processes in his body. To do this, he strives to eat as healthily as possible; to do this he avoids sugar and beverages plenty of water to stay hydrated while eating plenty of vegetables – taking supplements such as Resveratrol, Vitamin D3, Baby Aspirin and NMN (nicotinamide mononucleotide). All have demonstrated anti-ageing effects both animal studies as well as human studies.
Sinclair explores this research with Matthew LaPlante of Lifespan podcast fame in an episode of his podcast. They cover exercise that can increase longevity as well as non-dietary interventions known as Adversity Mimetics that mimic stressors to promote health and maintain wellbeing.
Sinclair believes meditation to be an integral component of his longevity routine, using apps such as Headspace and Yoga Wake Up to practice mindfulness – which he claims can improve both physical and mental wellbeing. Furthermore, he takes frequent breaks by walking around or engaging in weight lifting exercises.
Sinclair does his best to maintain good health, performing regular epigenetic tests and screenings for cancer. He obtains full-body AI-assisted MRI scans annually, checks blood markers using InsideTracker app, and refrains from making unsubstantiated claims about techniques or supplements he endorses.
Sinclair claims his biological age to be closer to 50. He attributes this remarkable feat to a healthy diet, an impressive supplement stack and regular exercise for maintaining his youthful look. Some key strategies he employs for maintaining such youthful vitality include forgoing sugary treats like alcohol and meat while opting for foods rich in polyphenols like berries, mushrooms and green tea instead.
Exercise
Exercise can help reverse or delay aging in many ways. Exercise helps maintain muscle mass, lower inflammation and boost metabolism; additionally it may improve cognitive function. For maximum effectiveness it should include both aerobic and strength training exercises in your daily regimen.
Sinclair’s research has demonstrated how revoking cells’ epigenetic clock can slow or even reverse aging. His team created temporary, fast-healing cuts in young mice’s DNA in order to mimic low-grade, ongoing DNA breaks experienced by mammalian cells daily due to breathing, exposure to sunlight or cosmic rays, chemical contact or exposure, all which contribute to damage or breakdown of information vital for proper cell functioning; once lost this can result in damage and rapid aging of tissues.
Sinclair and his lab have demonstrated the power to alter cell’s epigenetic history through cellular reprograming, giving new instructions that reset their epigenetic history and reverse aging processes in older mice. This breakthrough could potentially have profound ramifications for reverse human aging.
Sinclair’s work has generated widespread media interest, as many are curious to learn how they can extend longevity. Sinclair is distinguished in both research and business settings; with over 180 papers and numerous patents published as well as co-founding several biotechnology companies like Sirtris, Ovascience, Genocea and Cohbar as co-founders; additionally he served as president of the Academy for Health and Lifespan Research.
Sinclair has made exaggerated claims in the past about his discoveries, yet has pledged not to use such language going forward. This will likely increase accuracy in assessments of supplements and techniques while helping him rebuild trust within an increasingly disenchanted science community.
Dr. Sinclair and Matthew LaPlante from Lifespan podcast explore novel anti-aging interventions on the forefront. Topics discussed include testosterone replacement therapy, human growth hormone, peptides, exosomes, stem cells and cellular reprogramming research as well as experimental and clinical data for NAD boosters like metformin, resveratrol, berberine fisetin quercetin rapamycin and spermidine use.
Sleep
Sleep may be key to living longer. Research demonstrates that people who don’t get enough restful slumber are more prone to suffering from heart disease, obesity, diabetes and difficulty focusing, learning or remembering things due to insufficient production of chemicals necessary for these systems’ regulation; additionally sleep deprivation leads to increased levels of cortisol hormone, leading to quicker aging as well as increases in dementia, depression anxiety or Alzheimer’s disease risk.
To combat the effects of sleep deprivation, aim for six to eight hours of restful slumber each night, and try going to bed at roughly the same time each night. Additionally, implement an evening routine which helps you unwind before sleep – such as meditation or listening to soothing music – such as mediating or listening. Also avoid caffeine, alcohol and processed food at least a few hours prior to going to bed.
David Sinclair decided in his early 20s to dedicate his life to exploring the biology of aging. At first it wasn’t easy; other scientists often criticized his work, his lab was closed, funding issues surfaced and credibility concerns surfaced; but eventually positive results started appearing.
His breakthrough came in 2015 when he and his team reported they could turn back the biological clock of cells with three genes known as OSK. By rejuvenating cells back to a more youthful state, this technology offered hope of treating diseases associated with aging.
Today, Sinclair serves as both professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School; and holds 35 patents. In his career spanning aging research he has published over 180 papers on longevity issues as a regular contributor to top publications and media outlets; additionally he is also an active entrepreneur having co-founded companies including MetroBiotech, Cohbar InsideTracker Zymo EdenRoc Sciences Affiliates Segterra Life Biosciences as well as Life Biosciences affiliates etc.
Stress Management
Stress can be an understandable reaction to life changes and challenges; however, without proper management it can have serious adverse health repercussions. Stress has been linked with heart disease, muscle tension headaches and depression; its cause often stems from work related issues (money issues), relationships issues or relationship difficulties. You can manage your stress using various techniques including meditation and exercise – though healthy coping mechanisms such as drinking or smoking should be avoided as much as possible.
Sinclair has made quite an impactful mark in the longevity field with multiple publications and millions invested in his projects. He co-founded several companies such as Animal Bioscience and Life Biosciences which produce supplements he claims can reverse animal aging processes; however, other scientists recently accused him of overstating the results of his research.
His research centers around the idea that some genes, like sirtuins, can activate longevity pathways to slow aging. While not predetermined by nature, lifestyle choices such as diet and exercise can trigger these longevity genes to slow or reverse aging processes. He and his team have also identified natural products which may slow or reverse it like rapamycin.
He has been teaching longevity biology at Harvard Medical School since 1999, giving lectures all over the world about it. His research has been published in top-tier journals and he is a member of the Academy for Health and Longevity Research as well as receiving funding from sources such as National Institutes of Health.
He has served as both consultant and inventor on patents licensed to MetroBiotech, InsideTracker, Zymo, ArcBio and Liberty Biosecurity, in addition to owning equity ownership with Dovetail Genomics, Frequency Therapeutics and Elevian as well as board membership at Segterra, Cantata/Dovetail and Animal Biosciences. Furthermore, he was one of the founding investors in several other companies as well.
