What is the wave genome?
Since the 1990s, Russian scientists have proposed an idea known as the “wave genome.” According to this theory, DNA can be affected by waves at various scalar frequencies; such as acoustic, electromagnetic or quantum waves.
Wave Life Sciences Ltd. (Nasdaq: WVE) today announced a discovery collaboration with GSK plc that will accelerate Wave’s clinical pipeline of oligonucleotide therapeutics, such as its preclinical RNA editing program targeting alpha-1 antitrypsin deficiency (AATD), WVE-006. This four-year research term discovery collaboration.
To create an organism, two genetic programs are necessary. One program should contain geometric specifications for designing the body while the second contains instructions and explanations on how to use and understand the first program and build your organism.
Why is the wave genome important?
In 1990, the Department of Energy and National Institutes of Health launched the Human Genome Project: an ambitious endeavour designed to sequence all the DNA in humans. This “moonshot for biology” had as its goal the sequencing all individual’s genome.
Scientists have accomplished their goal and we now understand the sequence of all our genes, but what remains unknown is how they work together to form individuals. To gain a fuller understanding of how our genomes operate, it is necessary to study cell dynamics within our own bodies.
To do this, we are employing a cutting-edge technique called high-field optical microscopy. This innovative tool employs an ultrapowerful laser to record high-resolution movies of individual cells within living systems – showing their interconnection and how they coordinate activities to form organisms.
These findings offer our first glimpse of how genes are transmitted and activated during early development, and suggest a more general process of parental inheritance, pre-marking embryos with genes which later get erased and redeposited at later stages.
These results represent an important step toward understanding the biological foundation of inherited diseases, as well as developing strategies to treat them. Wave genome data will provide us with insight into molecular mechanisms of genetic disorders as well as providing a roadmap for using oligonucleotide-based therapeutics – small strands of DNA or RNA which have various capabilities of modulating or decreasing levels of RNA through multiple mechanisms.
How did the wave genome work?
Ashley Smart: There’s no doubt about it; the Human Genome Project was a monumental undertaking. It involved numerous scientific teams working for over 10 years at an estimated cost of $3 billion – truly an ambitious mission in biology!
Scientists used fragmentation of DNA followed by inserting each fragment into a different strain of bacteria until each fragment replicated successfully, to reconstruct the genome. By performing this procedure several times over, scientists could reassemble their genome.
Scientists used this technique to read all of the DNA that comprises an individual, but it left out one important piece of data – how all the genes connected one to another through an intricate network, giving shape and function to their genome. Now researchers believe that this web of information may exist as encoded waves within space that affect it – for example acoustic waves may alter it; electromagnetic and even scalar waves have an influence over it.
How can the wave genome help us?
Wave Life Sciences, a clinical-stage genetic medicines company, and GSK have joined forces to jointly discover therapeutic oligonucleotides targeting inherited diseases. As part of the discovery collaboration agreement, GSK will have exclusive global rights to Wave’s WVE-006 preclinical RNA editing program designed to treat alpha-1 antitrypsin deficiency (AATD).
In 1990, scientists embarked on the Human Genome Project–an ambitious undertaking many have likened to an Apollo mission–in an attempt to sequence every piece of DNA that constitutes humanity. It took years and billions of dollars for scientists to sequence our own individual genetic makeups – the foundation of humanity itself.
Russian scientists have reported that DNA can be affected by waves such as acoustic, electromagnetic and scalar waves; thus opening up a new field of science known as wave genome research.
