Wave and GSK are working in partnership on several oligonucleotide programs for treating multiple diseases, including Hepatitis B, Fatty Liver Disease (NAFLD) and AAT Diseases. Among them is Bepirovirsen – an antisense oligonucleotide entering Phase III for Hepatitis B treatment; WVE-006 an RNA Editing Program targeting AAT Disease; bepirovirsen, an antisense antisense oligonucleotide that will enter Phase III for Hepatitis B treatment; WVE-006 an RNA editing program for AATTD treatments.
Mating systems interact with selection to advance wave advance through strengthening of low density regions (LDs). Their significance remains unidentified.
What is Wave Genetics?
Wave Genetics‘ focus lies in discovering novel genomic variants using innovative approaches and an advanced platform. Their PRISM platform uses three RNA-targeting mechanisms (editing, splicing and antisense silencing) to generate therapeutic oligonucleotides for multiple therapeutic areas – with particular attention being paid to treating rare diseases like alpha-1 antitrypsin deficiency (AATD), one of which causes liver and lung damage. They have an established preclinical pipeline with potential to treat rare conditions like alpha-1 antitrypsin deficiency (AATD).
RNA is an essential building block of human DNA, and any changes in its structure have been linked with numerous human illnesses. When these modifications spread through populations, more favorable alleles become dominant over less desirable ones as the genetic wave progresses and advances; this phenomenon has been observed across various species – including humans.
Researchers using wave genetics have discovered that genetic variation among humans varies significantly across populations, with particular genes showing substantial variance from person to person.
Researchers of EEG recordings of brain waves called theta waves discovered, through an EEG (electroencephalogram) study, that one gene was associated with increasing amplitude (height) of these waves in Native Americans while only accounting for 4 percent of variability among North American whites.
This press release includes forward-looking statements as defined by the Private Securities Litigation Reform Act of 1995, as amended, including but not limited to statements regarding Wave’s collaboration and license agreement with GSK. These forward-looking statements are based on Wave’s current plans and expectations that could change due to various factors discussed under “Risk Factors” in its Annual Report on Form 10-K filed with the SEC on March 3, 2022 or in other filings it makes from time to time with the SEC.
Wave Genetics in Plants
Since Kary Mullis and Michael Smith received the Nobel Prize for their polymerase chain reaction – one of the major milestones of molecular genetics – only several years have passed since we saw Saccharomyces cerevisiae’s genetic sequence completed, followed by Arabidopsis’ sequence shortly afterwards (2001). We have also made great advances in genome scanning and mapping techniques; this allowing plant breeders to rapidly select high performing plants for further breeding; likely becoming one of the primary methods of crop improvement.
With new and advanced phenomics tools (NIRS), we are now capable of measuring multiple traits from a single field sample, which could revolutionize our ability to identify superior entries while shortening “Recycling Time” by 10 times, thus significantly decreasing seed costs and speeding crop improvement.
To unlock this potential, we must develop appropriate tools and approaches for managing, processing, and analyzing phenomics data. To do this effectively requires coalitions formed by plant scientists with the common aim of increasing availability and quality of phenomics data worldwide (Khan 2022).
Another pressing concern for plant breeders in the coming years will be accessing adequate diversity for breeding purposes. Genebanks with sufficient breadth and depth must be established so as to allow rapid development of high-performing crops; novel approaches for improving germplasm can then be developed through selective genotyping and sequencing (Nguyen & Norton 2020; Schulthess et al 2021).
As plant breeders become more adept in genetic advancement, many are beginning to explore pre-breeding (gerplasm enhancement). This method involves selecting superior individuals from existing varieties and then propagating them for further selection based on performance criteria. Pre-breeding has proven highly successful at increasing genetic progress over time and is increasingly used in plant breeding programs worldwide.
Wave Genetics in Animals
Spiritual teachers have long held that words and thoughts can rewrite genetic code; now this theory can be scientifically demonstrated as long as the right frequency is used. Russian researchers developed an ultrasonic wave gene transfer method which does not depend on host range; hence it can be applied both to animals and plants.
Wave genetics has also been applied to dogs with the discovery of the merle locus (104, 133) via retrotransposon insertion that affects pigmentation due to mutations of length polymorphisms of the MITF-M promoter; mutations that lead to the presence of either allele result in spots or solidness; allele sp produces spots while allele sw produces solidness.
Domestic yaks with white markings that resembled this gene mutation were profoundly deaf and displayed cochlear hair cell pathology similar to humans (202). Furthermore, mutations of KIT have been linked to horses with white patterns but without deafness (205), while Chinese Rongchang pig breeds show white patterns associated with deafness (209) although its cause has yet to be established.
Wave Genetics in Humans
Russian researchers have successfully employed Wave Genetics, an ancient form of communication between DNA and our bodies, for the first time ever. This technique works by employing special frequencies that entrain our bodies and give access to genetic information which can then be recorded and analyzed – similar to what esoteric and spiritual teachers have long asserted – that our body’s frequencies can be programmed using words, thoughts and emotions.
Research was performed using a frequency-stabilized Helium-Neon laser that was configured with two orthogonal optical modes. When modulated by its donor, this laser produced photons with modified spin states which could read genetic information from rudiments of dog teeth before spontaneously transforming into modulated broadband electromagnetic radiation (MBER) that contained this same data.
Following that, MBER was recorded with an atomic clock and video camera by measuring each photon as it passed through the tooth’s cellular membrane, before being converted into digital signals stored in a computer and displayed through images as part of an analysis program. Results demonstrated that there was a strong correlation between MBER and sequence of nucleotides found in DNA sample and MBER measurements.
Studies have demonstrated that DNA can produce waves when subjected to transcription, translation and replication processes or other cellular activities. Researchers theorize that the formation of electromagnetic waves results from interactions between quantum particles such as electrons and charged atoms with DNA structures’ vibrational frequencies, creating magnetic fields which in turn induce electric currents in its molecules. Wave forms produced by this interaction can then travel throughout the cell and outside, where they interact with particles such as proteins that vibrate at different rates, enabling DNA measurements to be taken and recorded, including its genetic code in each cell, recorded and analyzed, with its MBER providing insight into whether its genetic code has changed significantly through mutation. It also indicates whether its DNA remains stable.
