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Information Wellness Blog

Detailed Reviews and Guides about energy and informational health and wellness

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March 22, 2025|Editorial

Free Distant Healer India

Free distant healing can be used as a powerful tool for mental, physical, and spiritual wellbeing. Based on the theory that energy flows across space and time through intention alone, free distant healing works to heal all parts of yourself at once.

Healer Jasmmin, our founder Healer, holds a certificate as a Reiki Master. In addition, she has expanded her repertoire with Lama Fera, Pranic Healing, and Shalvik Mantra energy healing modalities.

Lama Fera

Lama Fera healing uses symbols to channel life force energy from the universe directly to patients. First practiced by Tibetan lamas, this powerful energy healing technique can remove negative energies from your body while increasing spiritual awareness and improving soul vitality. Furthermore, Lama Fera may help treat physical ailments or emotional concerns. For optimal results when learning Lama Fera seek out an experienced practitioner.

A Lama Fera Grandmaster must undergo an intensive training program and receive attunements or initiations from a certified teacher, learning symbols and mantras used in this ancient Tibetan healing modality as well as how to channel energy into patients. Furthermore, an intuitive spiritual connection should also be fostered during this practice.

Lama Fera is an effective energy healing system rooted in Tibetan Buddhism. Also referred to as the Buddha Healing Method, this healing practice uses Buddha’s power to bring about physical and mental wellbeing within humans. Additionally, its properties can help clear away negative energies in an environment, provide personal protection and spiritual awakening.

Lama Fera guru is renowned spiritual healer, offering guidance and support to his clients. In addition to offering workshops on various spiritual topics – energy healing, meditation and hypnotherapy among them – these sessions may take place either face-to-face or remotely as per client preference.

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He has been practicing spiritual healing for 15 years in Pune and offers Reiki and other energy healing techniques as a teacher. Additionally, he practices other spiritual arts such as Akashic Record Reading & Healing, Angelic Healing, Tarot Card reading and Shalvik Mantra depending on client requirements.

During healing sessions, energy healers channel positive energy into a client’s body, dispelling any blockages and rejuvenating their spirit. Sessions typically last an hour but can be extended upon mutual agreement; clients should keep in mind that energy healing does not replace conventional medical treatments or cure diseases.

Reiki

Reiki healing is an ancient Japanese healing art designed to relieve tension, reduce stress levels and promote emotional well-being. Reiki may also assist with physical ailments as it clears away energy blockages in your body’s ability to fight disease; though its scientific effectiveness remains unverifiable. Still, many health professionals have found reiki therapy an effective complement to conventional medical treatment approaches.

Reiki practitioners contend that all living things possess an energy known as “ki” or universal life force energy that runs through them, and when its flow decreases people become more stressed and susceptible to illness; when its levels rise it helps prevent disease while improving mental clarity – some even report curing serious illnesses through Reiki!

At a reiki session, the individual receiving therapy lies down and relaxes while their practitioner gently places their hands on or just above their body in various positions that correspond to chakras (energy centers). Although its exact mechanisms remain unknown, studies suggest it may promote relaxation, increase mental and emotional well-being as well as boost immune systems while encouraging self-healing processes.

“Reiki” is composed of two Japanese words – “rei” and “ki.” Rei is used to refer to universal spirit or higher power; while ki refers to the energy found within all living things. Reiki practice involves connecting with this energy; some practitioners believe it to be God; however others disagree and view it more as an unnamed higher power that fosters universalist thinking and positive energy.

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Mikao Usui, its founder, recommended that practitioners adhere to certain ethical ideals in order to promote peace and harmony between all peoples, such as treating all beings with respect, practicing an honor code of conduct, and refraining from harmful activities. These values transcend cultures regardless of religious belief, making the practice of Reiki suitable for use on its own as well as combined with other healing techniques such as massage therapy or yoga for treating various conditions.

Pranic Healing

Pranic healing is a non-contact energy therapy that harnesses prana, or life force energy, to restore harmony in the body’s energy systems. Practitioners utilize breathing techniques and hand movements to scan auras for imbalances and stimulate chakras; practitioners believe physical and emotional ailments often begin as energetic disruptions within an aura that need clearing in order to allow natural healing processes within our bodies to take effect.

Pranic Healing can be an excellent way to detoxify and improve overall health, clearing away mental clutter while decreasing stress levels. As an alternative to prescription drugs, Pranic Healing has proven highly successful at treating various conditions while improving sleep quality, immunity levels and energy levels – an effective tool in long-term recovery from substance abuse.

Stay hydrated and consume light meals prior to and following Pranic Healing sessions, avoiding pork, eel and catfish consumption as well as excessive alcohol use and addictive substances. Pranic Healing should only ever be performed by trained professionals.

This healing method is founded on the idea that our body’s natural ability to heal itself can be enhanced by increasing life energy (prana) in our system. It is an easy, straightforward, and noninvasive technique without medication or surgery – its principles based on Correspondence Law and Self Recovery Principle.

Pranic Healing operates under the principle that we all have an energy field known as an aura that absorbs and distributes prana throughout our bodies, which may be affected by mental, emotional or spiritual states. Psychologists have observed that many individuals experiencing illness also display disharmonies in their aura’s energy pattern; Pranic Healing can therefore help treat stress-related conditions like depression anxiety insomnia chronic pain digestive disorders etc.

Meditation can also help treat addiction by relieving cravings and improving focus. Furthermore, it may foster spiritual connections to the Universe.

Shalvik Mantra

SHALVVK is an effective spiritual mantra designed to bring peace and prosperity in life. It helps remove negative planetary effects as well as clear any negative energy in one’s home, office or business, protect from witchcraft/black magic as well as attract health, wealth, abundance and prosperity in one’s life. Anyone of any age and experience can easily use this tool; writing/pronouncing with emphasis on first syllable makes learning simple – great addition to healing practices!

Getcured is dedicated to offering only the highest-grade spiritual healing techniques to the world. Our skilled healers offer distant as well as in-person treatments and are here to assist with any ailments you might be suffering from. We focus on working on the energy layer of the aura – that subtle energetic field that encompasses and protects physical bodies.

Dr. S. K Saini created LAMA FERA Healing Techique between 1992-1995 as part of his Suksham Nadi Tantra Kosh Vigyan tradition, providing fast energy healing techniques that address physical, mental, emotional and spiritual ailments simultaneously. LAMA FERA works quickly by clearing away negative vibrations while welcoming positive energies into one’s energetic system – truly making this healing method unique in its nature!

Lama Fera is the combination of two words- ‘LAMA’ & ‘FERA’- each having their own identity and meanings. This energy healing system developed in monasteries in the Himalayas has been employed for centuries in clearing negative vibrations from one’s body energy field and helping individuals navigate life more smoothly and peacefully.

Healing Reiki can be an extremely powerful remedy for physical, emotional or spiritual imbalance. It can assist you in overcoming various challenges and problems of daily life to make every moment count and bring stability and happiness in relationships as well as protect you against curses, evil eyes or other forms of negativity.

March 22, 2025|Editorial

Amino Neuro Frequency Therapy

amino frequency therapy

ANF Therapy is an innovative holistic anti-inflammation solution. Wearable discs transmit frequencies that mimic your body’s natural frequencies to instantly reduce inflammation and pain within minutes.

These carbonized metal discs are activated by your body heat to release electrical frequencies that affect the nervous system and promote healing and production of antioxidants in your body.

Non-Invasive

Amino neuro frequency therapy is an innovative new therapy used to reduce inflammation in the body. Wearable discs designed to mimic natural frequencies within your own body help restore balance and promote healing – offering a holistic alternative to surgical approaches for pain management and healing. Not only is amino frequency therapy noninvasive; it’s also effective against treating many medical conditions.

Amino acids are building blocks of proteins and have numerous physiological roles, from cell function and growth regulation to strengthening immunity. Their multitude of advantages make intravenous (IV) amino acid therapy a viable treatment option for those coping with chronic health conditions requiring increased immunity.

IV amino acid therapy also enhances brain production of serotonin and gamma-aminobutyric acid (GABA), neurotransmitters that help reduce stress and anxiety, as well as promotes the synthesis of essential hormones such as glucocorticoids that provide proper fluid balance within the body. IV amino acid therapy provides an effective means of combatting stress and depression.

amino neuro frequency differs from other anti-inflammatory treatments in that it is completely noninvasive and chemical-free, safe for all ages, and doesn’t necessitate any dietary restrictions or special preparation. As such, this unique therapy can be used to treat various conditions including back and neck pain, headaches, fibromyalgia symptoms, sprains, and bruises.

ANF Therapy works on the principle that each cell in our bodies emits its own individual frequency, any disruptions to these frequencies resulting in imbalance and pain in the body. ANF Discs were specifically created to simulate these natural frequencies of our bodies to help realign and realign them – hence their effectiveness.

Each ANF disc contains specific frequencies designed to target specific parts of the body, with these waves transmitted through skin contact to stimulate natural cellular responses in your immune system and lower inflammation. Unlike traditional anti-inflammatory treatments, amino neuro frequency therapy works by targeting its source rather than just treating symptoms – providing lasting relief.

Natural

Amino neuro frequency therapy (ANFT) is a non-invasive technique designed to stimulate your body’s natural healing mechanisms and relieve pain and inflammation. As an effective alternative to traditional treatments, AMNT may offer solutions for various health issues and pain reduction.

amino neuro frequency therapy utilizes wearable discs that emit specific frequencies to reduce inflammation and stimulate natural healing processes in the body. With high patient satisfaction rates and safe usage, amino neuro frequency therapy offers an alternative way of alleviating pain naturally.

This technique can be combined with other therapies, like acupuncture and chiropractic care, to optimize their effects and deliver faster and longer-term relief from chronic pain and inflammation. ANF therapy is an invaluable way to restore balance in energy flows within the body as it supports natural healing processes.

ANF Academy provides clinical training to medical professionals on the principles of frequency medicine. Topics covered by this training include neurological oscillations, advanced palpation techniques and techniques used to assess nervous systems. The program has proven itself successful at managing injuries and pain effectively by targeting root causes rather than symptoms.

Neurofrequency therapy is a noninvasive, drug-free alternative to conventional treatment that may help address chronic fatigue, insomnia, anxiety and depression. Studies have also shown it improves sleep quality while strengthening immunity function; plus it may reduce stress and enhance athletic performance.

Inflammation is one of the leading causes of illness and pain, yet often goes undetected. Many don’t realize they’re experiencing inflammation even when it is manifesting through chronic symptoms like joint and muscle discomfort. At ANF we directly tackle inflammation by improving nerve signaling throughout the brain and other body parts.

ANF Therapy is a natural, safe and effective approach that has been shown to effectively alleviate pain and inflammation in numerous patients. Furthermore, ANF Therapy improves cell communication which aids recovery processes.

Effective

Amino Neuro Frequency therapy is an innovative new technique which has shown great promise for relieving pain and inflammation, improving overall wellness, and treating symptoms without surgery or medication. But it should not be seen as a magic bullet – rather used as part of a comprehensive treatment plan for best results.

Carbonized metal discs used in frequency therapy transmit various frequencies directly into the body. When placed over an affected area and heated by body heat, these discs emit low-level electrical frequencies that interact with and influence neural oscillations – helping reduce pain and inflammation and create harmony in the nervous system.

The amino frequency device is an innovative piece of technology that can complement other treatments, such as chiropractic care. Non-invasive and safe, it offers immediate pain relief while simultaneously treating its source. Addressing root cause rather than just masking symptoms helps decrease long-term risk for return.

ANF therapy can be utilized to treat various conditions, from chronic pain issues like fibromyalgia and arthritis to back issues and sprains. Along with helping reduce physical discomfort, ANF therapy also offers relief for mental stress as well as sleep disturbances while improving general well-being and energy levels.

Inflammation is the body’s natural response to injury or infection. While inflammation may provide helpful responses in certain circumstances, it should also be understood that inflammation may also pose serious dangers and lead to significant damage across multiple tissues and organs causing immense pain and dysfunction.

Amino frequency therapy (AFT) is an noninvasive and drug-free way of relieving pain and inflammation by activating your body’s natural healing processes. By targeting the source of inflammation, AFT therapy has proven itself immensely useful in helping people suffering from various health conditions.

Amino Neuro Frequency Therapy can be an extremely powerful and effective solution for many common health issues, including joint pain and inflammation. The therapy is simple to implement and may even help reduce medication dosage requirements – making it an attractive choice for people seeking alternatives to surgery or traditional medicines.

Safe

Amino frequency therapy stands out from other therapies by its lack of costly equipment, training and complex infrastructure required for implementation. Instead, its administration requires no cutting edge equipment or training while being totally noninvasive and side effect-free. Removable discs applied directly onto the body use this therapy to target areas of invisible inflammation while receiving frequencies from its neurons that stimulate self-healing mechanisms on cellular level to regulate and self-heal accordingly.

Invisible inflammation disrupts the body’s ability to form bonds among its various cells and tissues, potentially leading to chronic diseases and autoimmune conditions as well as interfering with natural frequencies that govern all bodily functions. ANF devices aim to restore these neurological frequencies in order to heal your body naturally.

ANF devices are made from NASA patented material and FDA certified as Class 1 medical devices. With no chemicals or drugs present, ANF devices are safe for people suffering from trypanophobia (fear of needles).

The ANF device’s discs contain a high-intensity electromagnetic field that sends correction signals into your body’s neuro frequencies to strengthen them and heal chronic diseases, autoimmune disorders, and many other forms of illness. Furthermore, therapy also works at helping overcome emotional or mental stressors that might be contributing to symptoms that cause discomfort.

Amino frequency therapy (ANF therapy) can provide relief for numerous forms of pain, such as backache, neckache, headaches and other chronic health conditions. ANF therapy can relieve inflammation while improving blood circulation and decreasing stress levels; furthermore it has the capability of treating herniated discs or orthopaedic injuries, treating depression or anxiety disorders and providing relief in general.

Traditional treatments were ineffective at providing relief to patients suffering from severe autoimmune disorders; however, new technology is making progress toward providing relief possible. Amino frequency therapy offers hope of alleviating their suffering while improving quality of life; however, before beginning this therapy it is advisable to consult a doctor first.

March 22, 2025|Editorial

Hulda Clark’s Mini Zapper

mini zapper hulda clark

Hulda Clark describes an electronic device known as a “zapper” in her book The Cure for All Diseases, including step-by-step instructions on how to construct one from Radio Shack parts and build one in an inexpensive shoe box.

It emits low frequency AC voltage with a 100% positive offset current that stimulates white blood cells to kill parasites and diseased tissue.

What is a zapper?

A zapper is an electrical bug repellent device that uses an electrified metal grid to kill flying insects. Designed primarily for outdoor use, they can be placed anywhere where mosquitoes pose a threat; typically gardens, porches, patios or decks. Attracting mosquitoes with light is usually enough to lure them onto its electric grid where they will die upon touching. Some models even come equipped with traps to collect dead bugs!

A quality zapper should have a durable housing that’s easily wipe-able clean. It may come in the shape of a lantern, cylinder or large rectangular cube; anti-tip designs prevent children and animals from touching its electrified grids inside. Furthermore, there are models designed specifically to kill bugs such as cockroaches, houseflies or spiders indoors.

PAYDAY 3’s Zapper lights up and emits a high-pitched whirr when activated, similar to how Discombobulators pulse periodically, before electrocuting players and terrain in its area nine times before despawning. Being hit by one will mark a player for some time preventing independent actions other than looking around, partially locking their facing direction, as well as stopping current weapons from firing until switching guns or completely turning off.

Why zap?

Hulda Clark makes bold claims that alternative health devices work, like her “zapper.” However, these assertions lack scientific credibility and have been disproven by independent studies.

A zapper is a simple electronic device that produces low-voltage pulses at 30 kHz (typically dual polarity 5V square wave). These pulses are sent out through copper handles or electrodes attached to copper handles held by users or placed over different parts of their bodies, with their hands. The idea behind using such frequencies to fight viruses, bacteria and parasites lies within their specific frequency of oscillation: when exposed to it they resonate with it and die off – helping detoxify and cleanse their bodies as a result.

How to use a zapper

Bug zappers use high-voltage electricity that kills parasites on contact, using a grid of copper wires as they fly through it. Most are designed for outdoor use near mosquito-rich environments like standing water or garbage cans; others may also be installed indoors near areas where mosquitoes tend to congregate such as sitting rooms. When installed in homes, they’re best installed away from areas where people sit or move about so as to reduce accidental contact with its electric grid as well as noise pollution from its operation.

Most bug zappers operate off of a 9-volt battery and contain a pulse generator circuit, two copper handles or electrodes, an outer housing (typically lantern-shaped or cylindrical), an integrated circuit designed to control pulse frequency of output, and an outer housing that may feature lantern shape or cylindrical shapes to protect children and pets from touching electrified grid inside. Many models also come equipped with integrated circuitry which enables frequency modulation for pulse output.

Modern zappers store the voltage for each electrical pulse on a capacitor that’s directly wired between their two screens, making this design more effective than earlier models which relied on batteries as sources for electrical pulse generation. Furthermore, eliminating the battery requirement and shrinking down overall device size are among the benefits provided by this design feature.

To operate the zapper, attach two alligator clips to its copper handles or electrodes and use clothing instead of Hulda Clark’s original hand holds to apply healing energy over larger surface areas of your body – particularly useful for women who may find Hulda’s hand holds confining or uncomfortable. Cloth that conducts electricity well will kill all parasites directly on contact.

While zappers are generally safe to use around children and pets, they should be placed out of reach to avoid becoming curiosity toys for either. Furthermore, placing it where it will be exposed to heat or sunlight may cause it’s plastic or metal parts to melt over time.

Accessories

A zapper operates off a 9v battery and emits low frequency waves which penetrate the user’s body, stimulating white blood cells while simultaneously infiltrating negative ions that kill parasites.

Dr. Hulda Clark introduced an updated version of her original Zapper device that is more durable, features an easier user experience, and includes a SenseAlert light to help ensure you connect correctly – this feature is extremely important to ensure no unnecessary zaps occur!

This zapper has a powerful output capable of killing fungi, bacteria and protozoa as well as parasites in the intestinal tract. Furthermore, its easy battery replacement compartment doesn’t require tools. In addition, its production involves degreed engineers on an ISO 9001 SMD assembly line to military level testing standards; guaranteeing you get exactly the output specified by Dr. Clark!

This bundle offers more than just a zapper: in addition to a short ebook on starting quickly and easily with zapping, there are great accessories like the Pet Pad contacts for use under feet or hands, Conductive Gloves that are suitable for children or adults, Conductive Gloves that make for excellent conductance measurements, Conductive Gloves that fit children as well as adults – making this package more than cost effective than ever in getting you healthy fast! Also included is the iZap app, for storing settings as well as creating logbooks; challenge friends in games to see who can beat you the farthest; please note this app is free download and use; however your data may be processed by Apple; please refer to developer privacy policy for more details.

March 22, 2025|Editorial

Energy Medicine by Dr Oschman

Scientific studies document the existence of energy fields within the body, as well as how their disruption by illness, disorder or injury, are altered. With clear language that makes understanding energy medicine simple for readers, this book helps readers comprehend its science as a potential form of healing therapy.

James Oschman has accomplished something truly revolutionary with this groundbreaking work by exploring traditional medical practices and alternative healing modalities such as acupuncture, Reiki and therapeutic touch. Through meticulous investigation of these healing techniques he provides scientific grounding for hands-on treatments like acupuncture, Reiki and therapeutic touch.

Weight-Training Injuries

Weight training is an effective and popular fitness routine for building strength; however, if not used appropriately or performed without prior conditioning to rigorous exercises it can also be dangerous. Misuse could result in injuries such as pain, swelling and reduced range of motion – symptoms which may not manifest immediately but will become increasingly noticeable as your injury heals.

Weight lifting injuries can affect any part of the body, but those most frequently affected are back, shoulder and knees. Commonly experienced injuries from weightlifting are muscle strains, bone fractures and herniated disks; children and adolescents using weights can also be at risk, though using proper conditioning techniques and injury prevention measures can significantly lower this number of injuries in this age group.

If a weight-training injury occurs, it’s crucial that medical attention be sought immediately. Depending on its severity, physical therapy or even surgery may be required – though most patients return to regular activity within months of being seen by a healthcare provider.

A strained quadriceps muscle is an often-experienced weight-training injury among individuals engaging in leg-centric exercises such as jump squats and box jumps. It typically results from engaging in high-impact exercises without sufficient rest between sessions, overtraining quads or employing improper form.

Lifting weights can injure the tendons and ligaments in your knee, including ACL tears, Patellar tendon tears or meniscus tears resulting in pain, swelling and difficulty moving your knee. Injuries to your shin bone, Achilles tendon or plantar fascia could also occur.

Herniated discs are serious injuries requiring medical care, often the result of incorrectly lifting heavy weights or suddenly increasing the frequency and amount of lifting over an extended period. Poor posture, dehydration and stress may also contribute to this injury; your physician can provide pain relievers and physical therapy sessions as a solution; in severe cases surgery may even be necessary to repair damaged ligaments and tendons.

Stress Management

Stress is a normal response to certain demands or events, but prolonged exposure to it can cause emotional and physical health issues. Luckily, there are ways to effectively manage it; techniques such as breathing exercises and relaxation therapy may help relieve acute as well as chronic forms of tension; while strategies that identify its sources and help combat them could prevent or alleviate symptoms altogether.

Stressful situations activate the body’s autonomic nervous system, triggering bodily functions like heart rate, breathing and vision changes as well as activating the fight-or-flight response that helps people respond to danger or perceived threats in an appropriate manner. Reactions may either be positive or negative depending on individual perception of each situation; experiences which could trigger stress include having a baby, going on vacation or receiving a promotion at work.

Stress symptoms may manifest physically, such as racing heartbeat and chest pain. Other symptoms are more mental or behavioral in nature, like anxiety or depression. Many people experience both types of stress simultaneously; doctors can assess one’s level of tension and suggest healthy solutions to reduce it.

Acute stress is short-term and dissipates quickly; for instance, before giving a presentation or getting into a fight with friends. Episodic acute stress occurs when people experience sudden feelings of unease every now and then; chronic stress has long-term ramifications on mood, sleep patterns and overall health – individuals experiencing this can find it challenging to complete daily tasks successfully.

Stress is part of life; we can all find ourselves stressed from time to time. Unfortunately, excessive levels can result in physical and psychological symptoms including high blood pressure, headaches, stomachaches, muscle tightness and chest pain that need treating either medically or through mental health services. Speaking to a doctor is one good way of finding relief; counselors or psychotherapists can teach various stress management strategies like cognitive behavioral therapy that help control reactions in stressful situations.

Pain Management

Pain management entails treating both the source of and symptoms associated with your discomfort. A pain doctor may prescribe medications or non-pharmacologic therapies like acupuncture and massage therapy to alleviate your suffering, as well as lifestyle modifications to enhance quality of life such as adding exercise into daily routine or changing diet; they may suggest keeping a pain diary to track when symptoms flare up as well as what improves or worsens them.

Pain management teams typically include doctors from multiple specialties, such as anesthesiology and neurology. Psychologists may be included to help patients cope with the emotional strain associated with managing pain. When you visit their clinic, your pain management physician will perform a full history and physical exam on you before reviewing all available information such as lab tests or imaging studies such as X-rays or CT scans; additionally they’ll discuss any other medical conditions you have or medications currently taken by you.

Your pain management strategy will vary depending on whether it is acute or chronic. Acute pain typically strikes suddenly and for short duration, such as after surgery or an injury; chronic pain occurs on an ongoing basis and ranges in intensity from mild to severe.

Before finding a treatment method that suits you, you will likely need to experiment with several approaches. Some of the more successful pain therapies include acupuncture, trigger point therapy and laser therapy; these treatments can reduce muscle spasms that lead to pain while interfering with exercise performance; laser therapy can also reduce inflammation while stimulating new tissue growth while increasing blood flow to an area.

Dr James Oschman is an internationally acclaimed scientist and author of energy medicine books. As one of the foremost authorities on hands-on healing practices, he has published in many leading scientific journals. In his book Energy Medicine: The Scientific Basis”, Dr Oschman details all of the scientific principles underpinning alternative healing modalities allowing mainstream health and wellness systems to embrace them more fully.

March 22, 2025|Editorial

Can a Scientist Reverse Aging in Mice?

scientist reverse aging mice

Scientists worldwide are competing to be the first to influence aging in people, an endeavor which would bring immense medical and economic advantages. This race to influence aging has now reached a fevered pitch.

Sinclair and her team used a virus to deliver three of the four Yamanaka factors into damaged retinal ganglion cells of aged mice, where it reversed shortened telomeres and rejuvenated the mice.

Epigenetics

Genes have an important impact on health and appearance, but so do other factors. Diet and exercise habits have the power to alter gene expression through epigenetics – unlike genetic mutations which directly change DNA sequence, epigenetics affects how our bodies read it instead.

Researchers are conducting extensive studies on how non-genetic factors impact an individual’s epigenetic profile – or how their genetic code is expressed – including its expression by non-genetic factors. Epigenetics was originally coined by Conrad Waddington in the 1940s to refer to molecular mechanisms that turn genotypes into phenotypes; today it more generally refers to heritable changes in gene function that do not involve DNA sequence changes.

Epigenetic mechanisms regulate access to chromatin, transcription, translation, mRNA splicing and its interactions with its targets as well as cell cycle regulation, differentiation and apoptosis – although some of these processes may be reversible while others cannot.

Some dietary habits may lead to the degradation of epigenetic marks that regulate how genes are expressed over time, leading to their expression behaving more like they’re older than they really are, leading to signs of premature aging in individuals.

Scientists have recently discovered that mammals keep a back-up copy of their youthful epigenetic profiles, which when restored can reverse age-related diseases like cancer, diabetes and Alzheimer’s. A team led by Harvard Medical School geneticist David Sinclair (not related to antiaging company Rejuvenate) demonstrated this approach with mice by administering a cocktail of chemicals which manipulate an enzyme involved in fixing DNA breaks – these mice lived 9% longer than untreated ones!

Sinclair and her team created mice engineered to experience DNA breaks three times more frequently than usual and administered their reprogramming drug; upon receiving treatment for DNA breaks faithfully repaired and epigenetic signatures returned to youthful patterns; giving the treated mice much younger appearances than untreated counterparts, while improving overall health status.

Cellular Reprogramming

Shinya Yamanaka and his Nobel Prize-winning team discovered a cocktail of proteins that reprogram adult cells into multipotent stem cells, giving rise to numerous benefits for health and disease prevention. Now, researchers are using these same tools to reverse the aging process in mice and, they hope, eventually humans. Already they’ve demonstrated they can turn back time in neuron cells, skin cells and connective tissue fibroblasts; experiments will soon extend this research onto nonhuman primates as well.

Reprogramming involves dramatic modifications to gene expression, chromatin status and other cell factors, often with long-term consequences on gene expression levels, transcription rates and down-regulation rates of age-associated genes. As a result, many cells fail to fully revert to their original state following OSKM induction; these have been labeled “partially reprogrammed.” Previously it was thought these partially reprogrammed cells had reached an irreversible point due to high reversion rates observed after its withdrawal; new research shows otherwise; cells that remain partially reprogrammed up until day 13 after OSKM induction still exhibit reduced epigenetic age, transcriptional age downregulation as well as down-regulation of age associated genes as well as more youthful genes such as collagens (see figure).

These results demonstrate that partial rejuvenation can be attained through extended reprogramming sessions. Furthermore, these results indicate it may be possible to achieve partial rejuvenation through using optimal conditions for reprogramming; specifically the use of optimal cell types like fibroblasts is necessary for successful reprogramming while small molecules to promote conversion should also be considered (see figure).

Understanding the steps and barriers associated with cell reprogramming and rejuvenation will enable strategies that could lead to clinical translation. This work will be further advanced through parallel implementation of technologies such as lineage tracing and event recording combined with longitudinal live tracking and sequencing techniques, providing enhanced temporal resolution for identifying key cell states and setting dynamic objectives that govern efficient reprogramming. Synthetic biology approaches that utilize signaling-regulatory networks can also be utilized during reprogramming to fine-tune desired outcomes (see figure). With these new tools at our fingertips, scientists will be able to better identify and target dynamic objectives behind cell reprogramming and rejuvenation processes.

Inducible Changes to the Epigenome (ICE)

Epigenetic changes within cells control which genes are turned on or off, helping ensure each cell produces only what they require for its specific function. If too many or too few proteins are produced by a cell, disease and even death could occur; the type of protein produced also depends on where that particular cell resides within the body – for instance, one needed for bone development is not produced in muscle cells, vice versa.

Scientists have long observed epigenetic changes associated with aging in mice and humans; however, scientists could never be certain whether these epigenetic alterations caused or simply resulted from it. To solve this conundrum, Sinclair’s team created temporary cuts in laboratory mice’s DNA that mimicked low-grade breaks experienced daily by mammalian cells; then they compared these “ICE” mice against Cre control mice on epigenetic status comparison.

Researchers discovered that ICE mice were epigenetically older than Cre controls using reduced representation bisulfite sequencing to measure CpG site methylation levels as an indicator of age; they discovered that the methylation levels among ICE mice were approximately 50 percent higher than in Cre control mice.

Researchers used RNA-Seq to compare the gastrocnemius muscle cells from ICE and Cre mice. They discovered that ICE cells expressed muscle-specific markers like Col1A1, Neurod1, and Nefh at lower levels than Cre cells; this suggested they were showing symptoms similar to aged mice, such as loss of muscle stem cells and an shift toward immune-skewed gene expression profiles.

Scientists conducted an experiment to see whether reversing epigenetic changes could slow or reverse their accelerated aging, using gene therapy with Oct4, Sox2, and Klf4. These pioneer transcription factors are active in mouse embryonic stem cells and have been found to rejuvenate human muscle tissue, likening their action to rebooting a malfunctioning computer. When administered via injection into ICE mice, gene therapy reduced various biomarkers of aging significantly – much like rebooting it.

Yamanaka Factors

Ten years ago, Kyoto University biologist Shinya Yamanaka won part of the Nobel Prize for discovering four genes that could reprogram adult cells into stem cells for use as versatile replacement organs, an advancement known as cellular reprogramming that may extend animal lives–possibly even ours! Since then, tech titans and venture capitalists have invested billions into labs trying to age-reverse mice’s DNA by altering it directly.

Researchers have used an innovative reversal technique to rejuvenate neurons of adult mice, finding that rejuvenated neurons improved synaptic connections, increased metabolism and even helped protect against neurodegenerative disorders like Alzheimer’s.

To achieve this, the team injected iPS cells into mice suffering from premature-ageing diseases and observed how these reprogrammed cells accelerated muscle regeneration and reversed behavioral deficits. Furthermore, scientists also reprogrammed cells from the hippocampus–an area involved with memory and learning–which resulted in less damage during aging as well as improved synaptic connections and memory function.

Researchers were amazed to discover that genetic factors that turn adult cells into iPS cells also rewound the “transcriptional clock,” restoring normal gene expression. Juan Carlos Izpisua Belmonte of the Gene Expression Laboratory at Salk Institute for Biological Studies explains that “transcriptional clock” refers to molecular mechanisms which regulate gene activity throughout development; its levels peak early and gradually decline as cells mature.

Resetting is controlled by proteins known as coregulators. Our team found that iPS cells express several of these coregulators known to play key roles in normal developmental processes. To identify coreregulators that play a role in delaying aging, the team conducted an exhaustive examination of genomic DNA changes in iPS cells using ChIP-chip. Analysis revealed a set of genes whose expression is essential to maintaining pluripotency, with results from an earlier ChIP-chip experiment showing these same genes are also involved in reprogramming. To facilitate their work, the team then utilized a system that enabled controlled expression of individual transcription factors (Oct4, Sox2, Klf4 and c-Myc). They did this in order to generate iPS cells with specific combinations of coregulators.

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