Borrelia burgdorferi infection of tick-borne Lyme disease bacteria leads to an early phase of illness which typically manifests itself with tick bites and an erythema migrans rash. Antibiotics like Doxycycline have proven successful at managing such early infections for most patients and helping avoid complications like arthritis.
Rife therapy offers an alternative approach in cases of antibiotic resistance; 10%-20% of patients fail to be completely rid of bacteria through antibiotic treatment, leaving symptoms behind.
Symptoms
Borrelia burgdorferi, a spirochaete bacteria which infects humans and animals alike, is responsible for Lyme disease. This infection is spread by ticks in the Ixodes genus; various strains of this pathogen, including Borrelia afzelii and Garinii which commonly infest European countries. Symptoms of Lyme disease begin with slowly expanding skin lesions known as Erythema Migrans at stage one before progressing to early disseminated infection with neurological abnormalities (stage 2) or later infections with arthritis in North America or Acrodermatitis chronica atrophicans (stage 3).
Serodiagnosis of early infections using ELISA or Western blot tests generally shows positive responses, generally of IgM isotype. However, up to 30% of patients without erythema migrans who tested negative. Antibiotic treatment typically clears away bacteria completely; hence asymptomatic infections usually resolve themselves; yet serological tests remain useful as monitoring mechanisms during therapy.
Early signs of late infections include joint pain and swelling that last from several weeks to many years in one or more joints. At first, symptoms usually affect only large joints like knees; if antibiotic treatment fails to alleviate symptoms effectively, long-term synovitis may ensue; MRI scans indicate this. Without antimicrobial therapy being effective enough, recurrent joints often display synovial cell hypertrophy and obliterative microvascular lesions caused by proinflammatory cytokines released by infected cells causing alterations; alterations due to an increase in proinflammatory cytokine production from cells containing proinflammatory cytokines releasing proinflammatory cytokines from inside infected cells causing synovial cell hypertrophy.
In the United States, one of the most frequently reported complications of Lyme disease is arthritis in one or more large joints; typically knees but it can affect any large joint. Symptoms typically appear within days to several years after initial exposure and often come with fatigue and fever. No direct evidence for person-to-person transmission exists; rather, immature ticks called nymphs are more likely to pass onto humans without detection than adult ticks; alternatively B. burgdorferi bacteria could ingest by animals like deer which carry it naturally before being passed onto humans via tick bite.
Causes
Up to 20% of patients treated with antibiotics fail to clear away all bacteria causing Lyme disease, leaving them with persistent symptoms including joint and muscle pain, fatigue and cognitive problems. Up until recently, researchers didn’t fully understand why such symptoms persisted after infection had been eliminated by antibiotics because bacteria can survive by hiding from immune systems in various locations in the body.
Post-Treatment Lyme Disease Syndrome (PTLDS) refers to these symptoms that arise after Lyme disease treatment has taken place and are associated with immune dysregulation, excessive inflammation, infection-induced autoimmunity or retained antigens from bacteria. Although its cause remains elusive, several studies have demonstrated that those experiencing PTLDS can be effectively treated by increasing levels of the anti-inflammatory cytokine IL-10 in their blood – known as RIFE treatment.
In the US, early Lyme disease is diagnosed by recognising characteristic clinical symptoms and positive serologic testing for IgM antibodies to B. burgdorferi; however, this test is insensitive during its acute phase when most patients present with erythema migrans rash. Acute treatment with Doxycycline antibiotic therapy shortens duration and prevents later manifestations such as Lyme arthritis in America or chronica atrophicans in Europe.
Even when prescribed antibiotics to combat late manifestations, many patients still suffer persistent symptoms that go undetected and often go misdiagnosed. Misdiagnosis can result in unnecessary use of antibiotics and contribute to the spread of antibiotic resistant strains that endanger everyone’s health. An excess of antibiotic use can also result in adverse side effects, including the Jarisch-Herxheimer reaction – caused by dying bacteria releasing neurotoxins into the environment – that can trigger reactions in skin, joints, heart, lungs and digestive tract that require prompt medical treatment to avoid fatality. Rife therapy uses resonant frequencies to destroy microorganisms and other potentially harmful substances in the body, and has proven successful against various diseases. Not only can it kill the bacteria that cause Lyme disease but it can also alleviate its associated pain.
Diagnosis
While most patients who contract Lyme disease will respond well to antibiotics, up to 20% may still experience long-term symptoms, including joint pain and memory problems. Scientists at Stanford University have discovered a compound called azlocillin that effectively eliminates bacteria responsible for such symptoms in mice; further research may reveal if its efficacy as a treatment option against Lyme disease in humans.
Lyme borreliosis (LB) is an infectious tick-borne disease caused by Borrelia burgdorferi bacteria in North America, while Borrelia afzelii or Borrelia garinii bacteria reside in Europe and Asia1. The name derives from Lyme, Connecticut where first documented patients showed symptoms including slowly expanding skin lesions (erythema migrans). Furthermore, Lyme can cause arthritis symptoms as well as neurologic manifestations which in some cases can even result in heart damage.
Immature ticks (nymphs) are more susceptible than adult ticks to infection due to being smaller and easier to overlook, which means bacteria spread by their bite can more quickly1. Infected nymph ticks transmit infections through bites of infected ticks1.
Lyme neuroborreliosis, an early disseminated disease, typically presents with fever, headaches, dizziness and cognitive issues such as fatigue or short-term memory loss. CNS involvement can vary widely, from abnormalities in testes and eyes to facial palsy or peripheral nerve weakness1.
Some months following antibiotic treatment of erythema migrans, some patients experience Relapsing Fever Lyme disease (RFL), also referred to as Posttreatment Lyme Disease Syndrome or PTLDS. Patients experiencing RFL often exhibit an increased incidence of arthritis – often an inflammatory and noninflammatory combination affecting one or multiple large joints – making their symptoms even more bothersome.
PTLDS may be linked to an immune system’s ineffectiveness at clearing bacteria away. Patients diagnosed with PTLDS often display low or undetectable antibody levels against B. burgdorferi bacteria, suggesting their bodies aren’t eliminating it efficiently.
Most patients with PTLDS tend to benefit from antibiotic treatment of RFL within weeks to months after starting anti-inflammatories or intra-articular corticosteroid injections; this improvement is primarily attributable to decreased inflammation in their joints which can be managed using NSAIDs or corticosteroid injections; although some develop persistent proliferative synovitis which needs treatment with DMARDs.
Treatment
Lyme disease affects over 300,000 Americans each year in the US alone and most cases occur in its northeastern region. Infection is caused by Borrelia burgdorferi bacteria which are transmitted via ticks belonging to Ixodes species. Disease symptoms from Legionella bacteria infection include fever, chills, fatigue, and joint pain. Once infected by Legionella bacteria, many individuals will go on to have chronic infections which are difficult to diagnose and treat. Rife Therapy offers a noninvasive solution for chronic Lyme disease infections known as post treatment Lyme disease syndrome (PTLDS), or chronic Lyme. Rife Therapy works to destroy dormant bacteria within your body that have lain dormant for some time now. Resonant frequency treatments are designed to affect the resonant frequencies of different organisms and body cells without harming other cells or harming Lyme disease spirochetes causing Lyme disease; by targeting their frequencies with these treatments, bacteria is killed off similar to how antibiotics do – only it doesn’t require taking pills and can be done at home!
Post-treatment Lyme disease syndrome or chronic Lyme disease occurs in some early neurological Lyme borreliosis patients after receiving antibiotic treatment; this condition is sometimes referred to as post-treatment Lyme disease syndrome or chronic Lyme disease and could have various causes, such as the bacteria remaining in muscle tissue or released from other cell sites during antibiotic treatment, excessive inflammation, immune dysregulation and presence of anti-B. burgdorferi antibodies in joints; for these individuals IL-10 has been associated with improved outcomes.
Arthritis is one of the hallmarks of Lyme borreliosis, particularly in knees and wrists, but can often be hard to distinguish from classic erythema migrans lesions with brighter red borders and bull’s-eye centres. One study demonstrated that treating Lyme patients with short courses of parenteral antibiotics followed by oral doxycycline significantly decreases duration of arthritis.
After experiencing neurological Lyme borreliosis, some patients can develop facial palsy and motor nerve weakness. A study conducted among antibiotic-treated patients in the US indicated that these symptoms typically resolve completely; however, in certain patients permanent nerve damage may remain permanent; similar research conducted among European patients showed only about 7% were able to fully regain function following functional limitations due to facial or motor weakness.
