A frequency-stabilized Helium-Neon laser was utilized to transfer genetic information from chromosomes into modulated broadband electromagnetic radiations carrying that same information, with nonlocality confirmed through polarization modification of probing photons. This gene-wave transmission method provides a potential method of quantum regeneration of canine teeth.
WAVE complex plays an essential role in mediating various cellular events, with any alterations to it linked to brain disorders. Dysregulation of WAVE-mediated cytoskeletal dynamics has been implicated in developmental disorders as well as adaptations to psychostimulants.
CYFIP2
CYFIP2 is an essential protein that interacts with WAVE1 and NCKAP1, contributing to over one hundred different protein-protein interactions and playing an integral part in actin dynamics network. Loss of this component could have serious repercussions for cell movement and transcription, neurodevelopmental disorders such as Early Infantile Epileptic Encephalopathy (EIEE) as well as potential variations CYFIP2, though its clinical implications remain under study.
The CYFIP2 gene has been associated with overexpression in several tumors and serves as a predictor for prognosis. Furthermore, its presence has been linked to tumor progression and resistance to chemotherapy treatments; additionally it could serve as an immunotherapeutic target.
In this study, we compared a cohort of 39 PAAD patients with high and low expression of CYFIP2 using GSEABase and GSVA R packages to assess differences between high and low expression groups for 28 immune-related genes. Results demonstrated that high CYFIP2 expression significantly inhibits migration and invasion by PAAD cells.
Variants in the CYFIP2 gene have been linked with EIEE, an illness characterized by neurological symptoms like muscular hypotonia and seizures. Although its impact is unclear due to limited evidence being reported in medical literature; putative CYFIP2 LoF variants do appear to show milder phenotypes than pathogenic missense variants.
Numerous CYFIP2 mouse models exhibit distinct phenotypes, suggesting that this gene plays an age-, region- and neuron-type-specific role. Furthermore, it has been noted that CYFIP2 interacts with several cellular processes including WRC activation and the phosphorylation of MAP Kinase.
